Name: KHK-2898
Brand: TargetMol
SKU: T9901A-1306
Rating: 4.5 (1 reviews)

生物活性

产品描述	KHK-2898 represents a highly specialized humanized monoclonal antibody specifically engineered to target the CD98 heavy chain (CD98hc/SLC3A2) with exceptional binding affinity to the human and monkey LAT1/CD98hc complex. It effectively facilitates the measurable blockade of amino acid transport and the induction of potent antibody-dependent cellular cytotoxicity (ADCC) across various preclinical experimental models to evaluate the disruption of tumor nutrient uptake and metabolic homeostasis during strictly monitored laboratory observation periods and functional cell viability assays.
体外活性	在表达人及猴 LAT1 的细胞系中，KHK-2898 以双重亲和模式结合 LAT1 并抑制了氨基酸摄取 [1]。
体内活性	在人肿瘤异种移植模型中，通过全身给药方式给予 KHK-2898 显著抑制了 LAT1 介导的营养摄取，表现出显著的抗肿瘤效果 [1]。
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	P08195
靶点	CD98

储存&溶解度

存储

KHK-2898