Name: KHK-2866
Brand: TargetMol
SKU: T9901A-1422
Rating: 4.5 (1 reviews)

生物活性

产品描述	KHK-2866 is a humanized monoclonal antibody targeting Heparin-Binding Epidermal Growth Factor-like Growth Factor (HB-EGF). By binding to HB-EGF, KHK-2866 blocks its interaction with EGFR and HER4 receptors, thereby inhibiting the proliferation and survival of tumor cells. HB-EGF is frequently overexpressed in various solid tumors, making it a key therapeutic target.
体外活性	在表达 Lat1 的人癌细胞系中，KHK-2866 展示了高亲和力结合，并有效抑制了氨基酸的摄取 [1]。
体内活性	在人肿瘤异种移植模型中，通过全身给药方式给予 KHK-2866，实验结果显示其通过阻断 Lat1 介导的营养转运显著抑制了肿瘤生长 [1]。
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG2SA

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	Q99075
靶点	HBEGF

化学信息

CAS No.

1832713-21-9

储存&溶解度

存储

KHK-2866