Homocarbonyltopsentin

Name: Homocarbonyltopsentin
Brand: TargetMol
SKU: T13723
Rating: 4.5 (1 reviews)

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产品编号 T13723Cas号 172286-77-0

别名 PK4C9

Homocarbonyltopsentin is a small-molecule TSL2-binding compound, binds to pentaloop conformations of TSL2 and promotes a shift to triloop conformations that display enhanced SMN2 exon 7 (E7) splicing (EC50: 16 μM).

Homocarbonyltopsentin

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产品编号 T13723 别名 PK4C9Cas号 172286-77-0

规格	价格	库存
25 mg	¥ 5,620	6-8周
50 mg	¥ 7,310	6-8周
100 mg	¥ 11,300	6-8周

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产品介绍

生物活性

产品描述	Homocarbonyltopsentin is a small-molecule TSL2-binding compound, binds to pentaloop conformations of TSL2 and promotes a shift to triloop conformations that display enhanced SMN2 exon 7 (E7) splicing (EC50: 16 μM).
体外活性	Homocarbonyltopsentin ?(40 μM; 24 hours) increased 1.5-fold SMN protein expression compared to GM03813C cells treated with DMSO.Homocarbonyltopsentin ?(10-40 μM; 24 hours) shows an up to 5.2-fold decrease in the expression of E7-excluding SMN2 isoforms, and up to three-fold increase in E7-including isoforms in GM03813C cells.
别名	PK4C9

化学信息

分子量	370.36
分子式	C₂₁H₁₄N₄O₃
CAS No.	172286-77-0
密度	1.539 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 125 mg/mL (337.51 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7001 mL	13.5004 mL	27.0008 mL	135.0038 mL
5 mM	0.5400 mL	2.7001 mL	5.4002 mL	27.0008 mL
10 mM	0.2700 mL	1.3500 mL	2.7001 mL	13.5004 mL
20 mM	0.1350 mL	0.6750 mL	1.3500 mL	6.7502 mL
50 mM	0.0540 mL	0.2700 mL	0.5400 mL	2.7001 mL
100 mM	0.0270 mL	0.1350 mL	0.2700 mL	1.3500 mL