Hepcidin-1 (mouse) TFA, an endogenous peptide hormone, regulates iron homeostasis by upregulating mRNA levels of TRAP, cathepsin K, and MMP-9, enhancing TRAP-5b protein secretion, and downregulating FPN1 protein levels, thereby increasing intracellular iron. It also promotes osteoclast differentiation [1].

Hepcidin-1（鼠）TFA在200-800 nM浓度下作用4天，能够增强RANKL（50 ng/mL）所诱导的RAW264.7细胞的分化过程[1]。在0-800 nM浓度范围内，Hepcidin-1（鼠）TFA作用4天可以提升TRAP、CTK和MMP-9 mRNA的表达水平[1]。同样，Hepcidin-1（鼠）TFA在0-800 nM浓度作用20小时会提高RAW264.7细胞中Trap-5b蛋白含量，并减少铁转运蛋白1（FPN1）蛋白的水平[1]。