Grapefruit Oil is a concentrated botanical extract shown to inhibit adipogenesis in cultured subcutaneous adipocytes. It suppresses the expression of key differentiation markers, including a 70% decrease in glycerol-3-phosphate dehydrogenase (GPDH) enzymatic activity at 50 µg/mL, while also reducing triglyceride accumulation in a dose-dependent manner from 50 to 400 µg/mL. The compound nearly doubles intracellular Ca²⁺ levels and downregulates PPAR gamma gene expression, making it a valuable tool for studying fat cell formation and lipid metabolism in cell-based research models.

Oils, grapefruit