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Efzofitimod 是组氨酰-tRNA 合成酶HARS1的剪接变体,由 HARS1 的免疫调节结构域融合人源抗体的 Fc 段构成。Efzofitimod 专注靶向神经磷脂NRP2 (neuropilin-2),展示出抗炎和免疫调节的特性。其能够在炎症疾病条件下下调先天性和适应性免疫反应,抑制间质性肺病 (ILD)。
Efzofitimod 是组氨酰-tRNA 合成酶HARS1的剪接变体,由 HARS1 的免疫调节结构域融合人源抗体的 Fc 段构成。Efzofitimod 专注靶向神经磷脂NRP2 (neuropilin-2),展示出抗炎和免疫调节的特性。其能够在炎症疾病条件下下调先天性和适应性免疫反应,抑制间质性肺病 (ILD)。

| 产品描述 | Efzofitimod is a splice variant of histidyl-tRNA synthetase HARS1, created by fusing the immunomodulatory domain of HARS1 with the Fc segment of a human antibody. It targets neuropilin-2 (NRP2) and exhibits anti-inflammatory and immunomodulatory properties. Efzofitimod can downregulate both innate and adaptive immune responses in inflammatory disease conditions, helping to mitigate interstitial lung disease (ILD). |
| 应用 | ELISA FACS Functional assay |
| 抗体种类 | Monoclonal |
| 内毒素 | <1.0 EU/mg |
| 偶联 | Unconjugated |
| CAS No. | 2566615-11-8 |
| 存储 | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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