DPPE-PEG1000 is a PEG lipid functional end group used for synthesizing liposomes (LPs) and is instrumental in designing conjugated polymer nanoparticles. Liposome nanoparticles (LNPs), featuring biotin modification and carboxyl terminals, can further couple with other biomolecules. These functionalized nanoparticles are useful for the targeted labeling of specific cell proteins. By employing streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles can bind to biotinylated antibodies on cell surface receptors, enabling applications in fluorescence-based imaging and sensing.