DMPE-PEG5000 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Liposomal nanoparticles (LNPs), with biotin modification and a carboxyl terminus, can further couple with other biomolecules. Functionalized nanoparticles target specific cell proteins for labeling. Utilizing streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles can bind to biotinylated antibodies on cell surface receptors, offering practicality in fluorescence-based imaging and sensing.