Name: Dendrotoxin-I TFA
Brand: TargetMol
SKU: T89619
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

待询

50 mg

待询

生物活性

产品描述	Dendrotoxin-I (DTX-I) TFA is an effective blocker of K+ channels, displaying IC50 values of 0.13-50 nM against voltage-gated potassium channel subunits KV1.1, KV1.2, and KV1.6. This neurotoxin also holds potential for use in cancer research.
靶点活性	Kv1.1 channel:0.13-50 nM, Kv1.6 channel:0.13-50 nM, Kv1.2 channel:0.13-50 nM
体内活性	Dendrotoxin-I在与高温治疗联合应用时,展现出明显的抗肿瘤效果(用药剂量为5 mg/kg;静脉给药).实验模型：植入MCF-7细胞的裸鼠[3].结果显示,初期治疗能显著抑制肿瘤生长,但在治疗后期未能持续抑制肿瘤增长.
别名	DTX-I TFA

化学信息

Sequence	Gln-Pro-Leu-Arg-Lys-Leu-Cys-Ile-Leu-His-Arg-Asn-Pro-Gly-Arg-Cys-Tyr-Gln-Lys-Ile-Pro-Ala-Phe-Tyr-Tyr-Asn-Gln-Lys-Lys-Lys-Gln-Cys-Glu-Gly-Phe-Thr-Trp-Ser-Gly-Cys-Gly-Gly-Asn-Ser-Asn-Arg-Phe-Lys-Thr-Ile-Glu-Glu-Cys-Arg-Arg-Thr-Cys-Ile-Arg-Lys (Disulfide bridge:Cys7-Cys57;Cys16-Cys40;Cys32-Cys53)
Sequence Short	QPLRKLCILHRNPGRCYQKIPAFYYNQKKKQCEGFTWSGCGGNSNRFKTIEECRRTCIRK (Disulfide bridge:Cys7-Cys57;Cys16-Cys40;Cys32-Cys53)

储存&溶解度

存储

Dendrotoxin-I TFA