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顶部产品介绍化学信息储存和溶解信息计算器

Dalfopristin (mesylate) (112362-50-2 free base)

Synonyms: Dalfopristin (mesylate)
货号 T22707 一键复制产品信息
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Dalfopristin (mesylate) is a streptogramin antibiotic and a 50S ribosome inhibitor. Streptogramins are produced by a variety of Streptomyces sp as a mixture (ratio of 7:3) of two chemically unrelated compounds, type A and B. Dalfopristin, the type A Streptogramin is often combined with type B streptogramin antibiotic, quinupristin, to produce Quinupristin-Dalfopristin Complex, known commercially as Synercid. The ribosome is composed of two ribonucleoprotein subunits, the 50S, and 30S. The 50S ribosome inhibitors inhibited protein synthesis.

Dalfopristin (mesylate) (112362-50-2 free base)

一键复制产品信息
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货号 T22707

别名 Dalfopristin (mesylate)

Dalfopristin (mesylate) is a streptogramin antibiotic and a 50S ribosome inhibitor. Streptogramins are produced by a variety of Streptomyces sp as a mixture (ratio of 7:3) of two chemically unrelated compounds, type A and B. Dalfopristin, the type A Streptogramin is often combined with type B streptogramin antibiotic, quinupristin, to produce Quinupristin-Dalfopristin Complex, known commercially as Synercid. The ribosome is composed of two ribonucleoprotein subunits, the 50S, and 30S. The 50S ribosome inhibitors inhibited protein synthesis.

Dalfopristin (mesylate) (112362-50-2 free base)
其他形式的 “Dalfopristin (mesylate) (112362-50-2 free base)”:
Dalfopristin
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规格价格库存数量
1 mg
¥ 4,610
3-6月
5 mg
¥ 14,990
3-6月
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产品介绍

生物活性
产品描述
Dalfopristin (mesylate) is a streptogramin antibiotic and a 50S ribosome inhibitor. Streptogramins are produced by a variety of Streptomyces sp as a mixture (ratio of 7:3) of two chemically unrelated compounds, type A and B. Dalfopristin, the type A Streptogramin is often combined with type B streptogramin antibiotic, quinupristin, to produce Quinupristin-Dalfopristin Complex, known commercially as Synercid. The ribosome is composed of two ribonucleoprotein subunits, the 50S, and 30S. The 50S ribosome inhibitors inhibited protein synthesis.
体外活性

Dalfopristin is a cyclic polyunsaturated macrolactone that interferes with the binding of tRNA substrates to both A- and P-sites [2]. Dalfopristin blocked the access of peptidyl-tRNAs to the ribosome and peptidyltransferase elongation reaction in bacteria [1]. quinupristin and dalfopristin acted synergistically to kill Gram-positive bacteria, as well as some Gram-negative and anaerobic bacteria [2][3]. Dalfopristin hydrolyzed rapidly to virginiamycin M under physiological conditions.

别名
Dalfopristin (mesylate)
化学信息
分子量787
分子式C34H51N4O9S·CH3SO3
SmilesO=C(/C=C/[C@@H](C)[C@@H](C(C)C)OC(C1N(CC[C@H]1S(CC[NH+](CC)CC)(=O)=O)C(C2=COC(C3)=N2)=O)=O)NC/C=C\C(C)=C\[C@@H](O)CC3=O.CS([O-])(=O)=O
密度no data available
储存&溶解度
存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息
Ethanol: Soluble
DMSO: Soluble

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

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