COX-2/HDAC6-IN-1 (Compound 11e) is a dual inhibitor targeting COX-2 and HDAC6 with an HDAC6 IC50 of 0.12 μM and a COX-2 IC50 of 0.66 μM. This compound enhances α-tubulin acetylation, regulates epigenetic gene expression, and inhibits the expression of pro-inflammatory mediators (COX-2, IL-1β, IL-6, and TNF-α). Additionally, COX-2/HDAC6-IN-1 promotes Amyloid-β clearance and reduces excessive phosphorylation of Tau protein. It supports neuronal morphology through MAP2 stabilization and maintains synaptic integrity by regulating synaptophysin, thereby restoring expression of memory-related genes. COX-2/HDAC6-IN-1 exhibits neuroprotective activity, improving learning and memory in Scopolamine-induced Alzheimer's disease mouse models. It is applicable for research related to Alzheimer's disease.

HDAC6:0.12 μM