Cortivazol is a phenylpyrazolosteroid compound that functions as a highly specific agonist for the glucocorticoid receptor, exhibiting negligible activation of the mineralocorticoid receptor. It binds to a distinct region of the ligand binding domain, establishing additional contacts with helices 3 and 5 for a more stable receptor configuration. In comparative studies, cortivazol demonstrates 165-fold greater potency than prednisolone and 7.5-fold higher activity than dexamethasone in cellular assays. This compound is used as a molecular probe to investigate glucocorticoid receptor structure-function relationships, ligand-dependent coactivator recruitment, and the selective regulation of gene expression pathways.

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