Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Chlorantraniliprole (Rynaxypyr) 是一种杀虫剂,能够有效地、选择性地激活鱼尼丁受体 (ryanodine receptor),对黑腹果蝇和烟芽夜蛾的 ryanodine 受体 EC50 值分别为 40 nM 和 50 nM,对其选择性是对小鼠骨骼肌 2C12 细胞 ryanodine 受体 (EC50,14 μM) 的 300 多倍。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 289 | 现货 | ||
25 mg | ¥ 493 | 现货 | ||
50 mg | ¥ 755 | 现货 | ||
100 mg | ¥ 1,080 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 318 | 现货 |
产品描述 | Chlorantraniliprole (Rynaxypyr) is an insecticide. Chlorantraniliprole potently and selectively activates insect ryanodine receptor, with EC50s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine receptor, and ∼300-fold more potent than that in the mouse myoblast cell line, C2C12 (EC50, 14 μM). |
体外活性 | Chlorantraniliprole potently and selectively activates insect ryanodine receptor. Chlorantraniliprole actions by release of intracellular Ca2+ stores mediated by the ryanodine receptor. Chlorantraniliprole is ∼300-fold less potent against ryanodine receptor (RyRs) in the mouse myoblast cell line, C2C12 (EC50, 14 μM), than in insect RyRs from Drosophila melanogaster and H. virescens (EC50, 40 nM, 50 nM), and shows little selectivity at the rat cell line RyR2 (EC50, >100 μM)[1]. |
体内活性 | Chlorantraniliprole has low acute mammalian toxicity with an acute oral LD50 of >5000 mg/kg in rats, and little to no toxicity in 90-day studies, at dosing as high as 1500 mg/kg/day[1]. |
别名 | Rynaxypyr, Chlorantranilipole, Rynaxpyr |
分子量 | 483.15 |
分子式 | C18H14BrCl2N5O2 |
CAS No. | 500008-45-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 56.7mg/mL (117.4mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.0698 mL | 10.3488 mL | 20.6975 mL | 51.7438 mL |
5 mM | 0.414 mL | 2.0698 mL | 4.1395 mL | 10.3488 mL | |
10 mM | 0.207 mL | 1.0349 mL | 2.0698 mL | 5.1744 mL | |
20 mM | 0.1035 mL | 0.5174 mL | 1.0349 mL | 2.5872 mL | |
50 mM | 0.0414 mL | 0.207 mL | 0.414 mL | 1.0349 mL | |
100 mM | 0.0207 mL | 0.1035 mL | 0.207 mL | 0.5174 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Chlorantraniliprole 500008-45-7 Others Rynaxypyr Chlorantranilipole Rynaxpyr Inhibitor inhibitor inhibit