Name: BMS-981164
Brand: TargetMol
SKU: T9901A-1097
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

¥ 3,950

待询

5 mg

待询

生物活性

产品描述	BMS-981164 is a humanized, tetravalent bispecific antibody designed to simultaneously target interleukin-4 receptor alpha (IL-4Rα) and interleukin-31 (IL-31). IL-4Rα is a critical component for both IL-4 and IL-13 signaling, driving Type 2 inflammation, while IL-31 plays a central role in inducing pruritus (itch). By dual blockade of these pathways, BMS-981164 inhibits the inflammatory cascade and alleviates itching symptoms. The antibody demonstrates high potency in researching chronic inflammatory skin diseases such as atopic dermatitis (AD) and offers superior pharmacological profiles compared to the combination of monospecific antibodies.
体外活性	BMS-981164 高亲和力结合 IL-4Rα 和 IL-31。其四价结构实现了对 IL-4/IL-13 介导的 STAT6 磷酸化及 IL-31 诱导的 STAT3 活化的亚纳摩尔 (nM) 级抑制，有效阻断炎症和致痒信号传导 [1]。
体内活性	在非人灵长类动物模型中，BMS-981164 剂量依赖性地抑制皮肤炎症和搔抓行为。该抗体有效靶向炎症组织，持久中和 Th2 炎症和瘙痒 [1]。
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型	IgG4SP-opti

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	Q6EBC2
靶点	IL-31

储存&溶解度

存储	store at low temperature \| store at -20°C \| Shipping with blue ice/Shipping at ambient temperature.

BMS-981164