Name: Anticancer peptoid 1
Brand: TargetMol
SKU: TP4479
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

待询

50 mg

待询

生物活性

产品描述	Anticancerpeptoid 1 (Peptoid 1) is a peptoid with antitumor activity, primarily exerting its cytotoxic effects by damaging the plasma membrane. It exhibits cytotoxicity against various cancer cell lines, including those with multidrug resistance. In human breast cancer xenograft mouse models, Anticancerpeptoid 1 effectively inhibits tumor growth without significant acute adverse effects. This compound is useful in cancer research, such as studies on breast and prostate cancer.
体外活性	Anticancer peptoid 1 在 72 h 处理后对 MCF-7、LNCaP、OVCAR-3、MRC-5 细胞及原代真皮成纤维细胞表现出强细胞毒性，LC50 值分别为 5、5、6、8 和 8 μM；Anticancer peptoid 1 (0-50 μM; 72 h) 对 MCF-7 细胞及多药耐药 MCF-7/TxT50 细胞也具有显著细胞毒性，从而逆转多药耐药性；此外，Anticancer peptoid 1 (50 μM; 5-60 min) 可在 MCF-7 细胞中快速诱导质膜损伤，短期处理后可导致约 50% 的 LDH 泄漏。
体内活性	抗癌化合物 peptoid 1 (1 mg/kg；乳腺脂肪垫注射；每周 3 次；共 12 周) 在人乳腺癌原位异种移植小鼠模型中有效抑制肿瘤生长，未出现急性毒性反应。
别名	Peptoid 1

化学信息

分子量	1819.32
分子式	C₁₀₄H₁₃₉N₁₇O₁₂
CAS No.	620948-14-3
Smiles	N([C@@H](C)C1=CC=CC=C1)(C(CN([C@@H](C)C2=CC=CC=C2)C(CN(C(CN([C@@H](C)C3=CC=CC=C3)C(CN([C@@H](C)C4=CC=CC=C4)C(CNCCCCN)=O)=O)=O)CCCCN)=O)=O)CC(N(CC(N([C@@H](C)C5=CC=CC=C5)CC(N([C@@H](C)C6=CC=CC=C6)CC(N(CC(N([C@@H](C)C7=CC=CC=C7)CC(N([C@@H](C)C8=CC=CC=C8)CC(N)=O)=O)=O)CCCCN)=O)=O)=O)CCCCN)=O

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

Anticancer peptoid 1