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Anti-IL6R Monoclonal Antibody

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产品编号 TMAZ-0053
别名 Membrane glycoprotein 80, Interleukin-6 receptor subunit alpha, IL-6R 1

Anti-IL6R Monoclonal Antibody is a humanized rabbit antibody targeting IL6R. Anti-IL6R Monoclonal Antibody can be used in FCM. 可用于 ELISA,FCM,IF。

Anti-IL6R Monoclonal Antibody

Anti-IL6R Monoclonal Antibody

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产品编号 TMAZ-0053 别名 Membrane glycoprotein 80, Interleukin-6 receptor subunit alpha, IL-6R 1

Anti-IL6R Monoclonal Antibody is a humanized rabbit antibody targeting IL6R. Anti-IL6R Monoclonal Antibody can be used in FCM. 可用于 ELISA,FCM,IF。

规格价格库存数量
25 μg
¥ 1,250
7日内发货
50 μg
¥ 1,500
7日内发货
100 μg
¥ 2,099
7日内发货
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浓度:0.69 mg/mL
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产品介绍

生物活性
产品描述
Anti-IL6R Monoclonal Antibody is a humanized rabbit antibody targeting IL6R. Anti-IL6R Monoclonal Antibody can be used in ELISA,FCM,IF.
别名Membrane glycoprotein 80, Interleukin-6 receptor subunit alpha, IL-6R 1
Ig Type
Rabbit monoclonal IgG
交叉反应
Human
验证活性
Flow cytometry analysis of IL-6R overexpressed 293F cells with TMAZ-0053BI, which was counjucated with SA-PE (red). The WT 293F control is black line.
应用ELISAFCMIF
推荐剂量
0.1-0.2 μg/10E6 cells for FCM; 1 ng/μl for ELISA
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Single-pass type I membrane
构建方式This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of IL-6R protein.
纯化方式Protein A Affinity Purified
性状Liquid
缓冲液0.22 μm filtered solution in PBS.
纯度> 95% as determined by SDS-PAGE.
研究背景Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal (PubMed: 28265003). Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis (PubMed: 30995492, PubMed: 31235509). The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6: IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable)|Signaling via the membrane-bound IL6R is mostly regenerative and anti-inflammatory (Probable). Drives naive CD4(+) T cells to the Th17 lineage, through 'cluster signaling' by dendritic cells (By similarity)|Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity (PubMed: 21990364). The IL6: sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases (PubMed: 21990364). In complex with IL6, is required for induction of VEGF production (PubMed: 12794819). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (By similarity)|Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity (PubMed: 21990364). The IL6: sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases (PubMed: 21990364). In complex with IL6, is required for induction of VEGF production (PubMed: 12794819). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (By similarity)
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Biotin
可提供抗体种类
2
抗原信息
免疫原
IL-6R
抗原种属
Human
基因ID
3570
Uniprot ID
P08887
研究领域
Immunology Research, Cancer Research
化学信息
分子量150 kDa
颜色Transparent
物理性状Liquid
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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