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Anti-CHGA Monoclonal Antibody

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产品编号 TMAZ-0139

别名 Pituitary secretory protein I, Chromogranin-A

Anti-CHGA Monoclonal Antibody is a humanized rabbit antibody targeting CHGA. Anti-CHGA Monoclonal Antibody can be used in ELISA, FCM. 可用于 ELISA,FCM。

Anti-CHGA Monoclonal Antibody

Anti-CHGA Monoclonal Antibody

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产品编号 TMAZ-0139 别名 Pituitary secretory protein I, Chromogranin-A

Anti-CHGA Monoclonal Antibody is a humanized rabbit antibody targeting CHGA. Anti-CHGA Monoclonal Antibody can be used in ELISA, FCM. 可用于 ELISA,FCM。

规格价格库存数量
25 μg
¥ 1,250
7日内发货
50 μg
¥ 1,500
7日内发货
100 μg
¥ 2,099
7日内发货
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产品介绍

生物活性
产品描述
Anti-CHGA Monoclonal Antibody is a humanized rabbit antibody targeting CHGA. Anti-CHGA Monoclonal Antibody can be used in ELISA,FCM.
别名Pituitary secretory protein I, Chromogranin-A
Ig Type
Rabbit monoclonal IgG
交叉反应
Human
验证活性
Flow cytometry analysis of CHGA overexpressed 486F cells with TMAZ-0139, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line).
应用ELISAFCM
推荐剂量
0.1-0.2 μg/10E6 cells for FCM; 1 ng/μl for ELISA
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Single-pass type I membrane
构建方式This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CHGA protein.
纯化方式Protein A Affinity Purified
性状Liquid
缓冲液0.22 μm filtered solution in PBS.
纯度> 95% as determined by SDS-PAGE.
研究背景Strongly inhibits glucose induced insulin release from the pancreas|Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed: 15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed: 15723172, PubMed: 24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed: 21214543). Acts as a potent scavenger of free radicals in vitro (PubMed: 24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed: 18541522)|Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Biotin
可提供抗体种类
2
抗原信息
免疫原
CHGA
抗原种属
Human
基因ID
1113
Uniprot ID
P10645
研究领域
Cancer Research
化学信息
分子量150 kDa
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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