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Anti-ZEB1/NIL2A Polyclonal Antibody 2

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货号 TMAB-14286

Anti-ZEB1/NIL2A Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 ZEB1/NIL2A。Anti-ZEB1/NIL2A Polyclonal Antibody 2 可用于 WB。

Anti-ZEB1/NIL2A Polyclonal Antibody 2

Anti-ZEB1/NIL2A Polyclonal Antibody 2

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Rating icon 还可以
货号 TMAB-14286

Anti-ZEB1/NIL2A Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 ZEB1/NIL2A。Anti-ZEB1/NIL2A Polyclonal Antibody 2 可用于 WB。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-ZEB1/NIL2A Polyclonal Antibody 2 is a Rabbit antibody targeting ZEB1/NIL2A. Anti-ZEB1/NIL2A Polyclonal Antibody 2 can be used in WB.
Ig Type
IgG
反应种属
Human,Mouse (predicted:Rat,Chicken,Dog,Pig,Cow,Rabbit,Sheep)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus.
组织特异性Colocalizes with SMARCA4/BRG1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010]
抗原信息
免疫原
KLH conjugated synthetic peptide: human ZEB1/NIL2A
抗原种属
Human
基因名称
ZEB1
基因ID
6935
蛋白名称
Zinc finger E-box-binding homeobox 1
Uniprot ID
P37275
功能
Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.
化学信息
分子量Theoretical: 124 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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