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顶部生物活性储存和溶解信息计算器

Anti-XRN2 Antibody (1B629)

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Anti-XRN2 Antibody (1B629)
产品编号 TMAC-04303
别名 XRN 2, DHP protein, DHM1 like protein, 5' 3' exoribonuclease 2

Anti-XRN2 Antibody (1B629) 是一种 Mouse 抗体，靶向 XRN2。Anti-XRN2 Antibody (1B629) 可用于 WB,IHC。

Anti-XRN2 Antibody (1B629)

Anti-XRN2 Antibody (1B629)

Rating icon 还可以
Anti-XRN2 Antibody (1B629)
产品编号 TMAC-04303 别名 XRN 2, DHP protein, DHM1 like protein, 5' 3' exoribonuclease 2

Anti-XRN2 Antibody (1B629) 是一种 Mouse 抗体，靶向 XRN2。Anti-XRN2 Antibody (1B629) 可用于 WB,IHC。

规格价格库存数量
50 μL
¥ 1,995
5日内发货
100 μL
¥ 2,995
5日内发货
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产品介绍

生物活性
产品描述
Anti-XRN2 Antibody (1B629) is a Mouse antibody targeting XRN2. Anti-XRN2 Antibody (1B629) can be used in WB,IHC.
别名XRN 2, DHP protein, DHM1 like protein, 5' 3' exoribonuclease 2
交叉反应
Human
验证活性
1. Western blot analysis of XRN2 on human XRN2 recombinant protein using anti-XRN2 antibody at 1/1,000 dilution.
2. Western blot analysis of XRN2 on HEK293 (1) and XRN2-hIgGFc transfected HEK293 (2) cell lysate using anti-XRN2 antibody at 1/1,000 dilution.
3. Western blot analysis of XRN2 on different cell lysate using anti-XRN2 antibody at 1/1,000 dilution. Positive control: Lane1: Raw264.7, Lane2: HEK293, Lane3: NTERA-2, Lane4: LNcap, Lane5: HepG2, Lane6: HEK293, Lane7: Hela.
4. Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-XRN2 antibody. Counter stained with hematoxylin.
5. Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissue using anti- XRN2 antibody. Counter stained with hematoxylin.
应用
WB
IHC
推荐剂量
WB: 1:500-2000; IHC: 1:200-500
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Degradation of mRNA is a critical aspect of gene expression that occurs via the exoribonuclease. Exoribonuclease 2 (XRN2) is the human homologue of the Saccharomyces cerevisiae RAT1, which functions as a nuclear 5' to 3' exoribonuclease and is essential for mRNA turnover and cell viability. XRN2 also processes rRNAs and small nucleolar RNAs (snoRNAs) in the nucleus. XRN2 moves along with RNA polymerase II and gains access to the nascent RNA transcript after the endonucleolytic cleavage at the poly(A) site or at a second cotranscriptional cleavage site (CoTC). CoTC is an autocatalytic RNA structure that undergoes rapid self-cleavage and acts as a precursor to termination by presenting a free RNA 5' end to be recognized by XRN2. XRN2 then travels in a 5'-3' direction like a guided torpedo and facilitates the dissociation of the RNA polymerase elongation complex.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
Q9H0D6
化学信息
分子量Theoretical: 109 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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