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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-XRCC4 Antibody (7H105)

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货号 TMAB-14220

Anti-XRCC4 Antibody (7H105) 是一种 Mouse 抗体，靶向 XRCC4。Anti-XRCC4 Antibody (7H105) 可用于 IHC-P,IHC-Fr,IF。

Anti-XRCC4 Antibody (7H105)

Anti-XRCC4 Antibody (7H105)

一键复制产品信息
Rating icon 还可以
货号 TMAB-14220

Anti-XRCC4 Antibody (7H105) 是一种 Mouse 抗体，靶向 XRCC4。Anti-XRCC4 Antibody (7H105) 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
200 μg
¥ 5,580
5日内发货
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-XRCC4 Antibody (7H105) is a Mouse antibody targeting XRCC4. Anti-XRCC4 Antibody (7H105) can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
克隆号
7H105
反应种属
Human
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Monoclonal
宿主来源Mouse
亚细胞定位Nucleus.
组织特异性Widely expressed.
构建方式Hybridoma Monoclonal Antibody
纯化方式Protein G purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad51. XRCC1 is a protein that facilitates the DNA base excision repair pathway by interacting with DNA ligase III and DNA polymerase to repair DNA single-strand breaks. XRCC2 and XRCC3 are both involved in maintaining chromosome stability during cell division. XRCC2 is required for efficient repair of DNA double-strand breaks by homologous recombination between sister chromatids, and XRCC3 interacts directly with Rad51 to cooperate with Rad51 during recombinational repair. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination. Any defect in one of the known components of the DNA repair/V(D)J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA ligase IV) leads to abortion of the V(D)J rearrangement process and early block in both T and B cell maturation.
抗原信息
免疫原
Recombinant Protein: human XRCC4 protein
抗原种属
Human
基因名称
XRCC4
基因ID
7518
蛋白名称
DNA repair protein XRCC4
Uniprot ID
Q13426
功能
Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
化学信息
分子量Theoretical: 38 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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