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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-WFS1 Polyclonal Antibody

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货号 TMAB-14173

Anti-WFS1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 WFS1。Anti-WFS1 Polyclonal Antibody 可用于 WB。

Anti-WFS1 Polyclonal Antibody

Anti-WFS1 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-14173

Anti-WFS1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 WFS1。Anti-WFS1 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-WFS1 Polyclonal Antibody is a Rabbit antibody targeting WFS1. Anti-WFS1 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Dog,Cow,Horse)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Endoplasmic reticulum; endoplasmic reticulum membrane; multipass membrane protein
组织特异性Highly expressed in heart followed by brain, placenta, lung and pancreas. Weakly expressed in liver, kidney and skeletal muscle. Also expressed in islet and beta-cell insulinoma cell line.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Wolfram syndrome protein (WFS1) is an 890 amino acid protein that contains a cytoplasmic N-terminal domain, followed by nine-transmembrane domains and a luminal C-terminal domain. WFS1 is predominantly localized to the endoplasmic reticulum (ER) (1) and its expression is induced in response to ER stress, partially through transcriptional activation (2,3). Research studies have shown that mutations in the WFS1 gene lead to Wolfram syndrome, an autosomal recessive neurodegenerative disorder defined by young-onset, non-immune, insulin-dependent diabetes mellitus and progressive optic atrophy (4).
抗原信息
免疫原
KLH conjugated synthetic peptide: human WFS1
抗原种属
Human
基因名称
WFS1
基因ID
7466
蛋白名称
Wolframin
Uniprot ID
O76024
功能
WFS1 is a novel component of Wolfram syndrome, a rare form of juvenile diabetes. WFS1 plays an important role in maintaining homeostasis of the endoplasmic reticulum (ER) in the pancreas. It is normally up-regulated during insulin secretion, whereas inactivation of the protein can cause ER stress. Chronic ER stress is a major involvement in Wolfram syndrome.
化学信息
分子量Theoretical: 97 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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