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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-VHL Polyclonal Antibody 2

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货号 TMAB-14097

Anti-VHL Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 VHL。Anti-VHL Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF,FCM。

Anti-VHL Polyclonal Antibody 2

Anti-VHL Polyclonal Antibody 2

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Rating icon 还可以
货号 TMAB-14097

Anti-VHL Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 VHL。Anti-VHL Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF,FCM。

规格价格库存数量
50 μL
¥ 1,165
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100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-VHL Polyclonal Antibody 2 is a Rabbit antibody targeting VHL. Anti-VHL Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF,FCM.
Ig Type
IgG
反应种属
Human,Rat (predicted:Mouse,Dog,Cow)
应用IHC-PIHC-FrIFFCM
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Isoform 1: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=Found predominantly in the cytoplasm and with less amounts nuclear or membrane-associated. Colocalizes with ADRB2 at the cell membrane. Isoform 3: Cytoplasm. Nucleus. Note=Equally distributed between the nucleus and the cytoplasm but not membrane-associated.
组织特异性Expressed in the adult and fetal brain and kidney
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes a component of a ubiquitination complex. The encoded protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. In addition to oxygen-related gene expression, this protein plays a role in many other cellular processes including cilia formation, cytokine signaling, regulation of senescence, and formation of the extracellular matrix. Variants of this gene are associated with von Hippel-Lindau syndrome, pheochromocytoma, erythrocytosis, renal cell carcinoma, and cerebellar hemangioblastoma. [provided by RefSeq, Jun 2022]
抗原信息
免疫原
KLH conjugated synthetic peptide: human VHL
抗原种属
Human
基因名称
VHL
基因ID
7428
蛋白名称
von Hippel-Lindau disease tumor suppressor
Uniprot ID
P40337
功能
Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.
化学信息
分子量Theoretical: 24 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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