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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Uroplakin Ia Polyclonal Antibody

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货号 TMAB-14005

Anti-Uroplakin Ia Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Uroplakin Ia。Anti-Uroplakin Ia Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-Uroplakin Ia Polyclonal Antibody

Anti-Uroplakin Ia Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-14005

Anti-Uroplakin Ia Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Uroplakin Ia。Anti-Uroplakin Ia Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,165
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100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

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产品描述
Anti-Uroplakin Ia Polyclonal Antibody is a Rabbit antibody targeting Uroplakin Ia. Anti-Uroplakin Ia Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Pig,Cow,Horse,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Membrane; Multi-pass membrane protein.
组织特异性High expression restricted to ureteric urothelium (most superficial cells); low expression in prostate. Expression in normal urothelial cells is lost in culture. Some expression in tumor cell lines derived from urothelial malignancies.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The asymmetric unit membrane (AUM) forms numerous plaques, which cover the apical surface of the urothelium. These plaques are thought to strengthen the urothelium and reduce the risk of rupturing during ladder distention. They are composed of four major integral membrane proteins called uroplakins (UP). The uroplakin family comprises UPIa, UPIb, UPII, and UPIII. Family members are conserved among several species, including human, mouse, rat, rabbit, dog, pig and sheep. UPIa and UPIb form tightly packed structures with UPII and UPIII, respectively. This pairing is required for normal urothelial plaque formation and is regulated by proteolytic processing of the uroplakin proteins. Uroplakins are expressed in normal urothelium and are used as specific markers of urothelial differentiation. They are also expressed in a majority of transitional cell carcinomas of the bladder (TCCs), which make the uroplakins a useful marker for detecting bladder cancer metastasis and for staging and monitoring chemotherapeutic response.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Uroplakin Ia
抗原种属
Human
基因名称
UPK1A
基因ID
11045
蛋白名称
Uroplakin-1a
Uniprot ID
O00322
功能
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.
化学信息
分子量Theoretical: 29 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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