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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-ULK1 Antibody (9F998)

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货号 TMAB-13989

Anti-ULK1 Antibody (9F998) 是一种 Rabbit 抗体，靶向 ULK1。Anti-ULK1 Antibody (9F998) 可用于 WB,IHC-P,IF,IHC-Fr。

Anti-ULK1 Antibody (9F998)

Anti-ULK1 Antibody (9F998)

一键复制产品信息
Rating icon 还可以
货号 TMAB-13989

Anti-ULK1 Antibody (9F998) 是一种 Rabbit 抗体，靶向 ULK1。Anti-ULK1 Antibody (9F998) 可用于 WB,IHC-P,IF,IHC-Fr。

规格价格库存数量
25 μL
¥ 790
5日内发货
50 μL
¥ 1,395
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

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产品描述
Anti-ULK1 Antibody (9F998) is a Rabbit antibody targeting ULK1. Anti-ULK1 Antibody (9F998) can be used in WB,IHC-P,IF,IHC-Fr.
Ig Type
IgG
克隆号
9F998
反应种属
Human,Mouse,Rat
应用WBIHC-PIFIHC-Fr
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IF: 1:100-500; IHC-Fr: 1:100-500
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cytoplasm, cytosol. Preautophagosomal structure. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome.
组织特异性Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究背景ULK1 belongs to the serine/threonine protein kinase family. It is involved in axon growth and plays an essential role in neurite branching during sensory axon outgrowth. Knockdown of ULK1 results in impaired endocytosis of nerve growth factor (NGF), excessive axon arborization, and severely stunted axon elongation indicating that ULK1 mediates a non clathrin coated endocytosis in sensory growth cones. Knockdown of ULK1 also inhibits the autophagic response. It appears to act as a convergence point for multiple signals that regulate autophagy, and in turn interacts with a large number of autophagy related (Atg) proteins.
抗原信息
免疫原
A synthesized peptide: human ULK1
抗原种属
Human
基因名称
ULK1
基因ID
8408
蛋白名称
Serine/threonine-protein kinase ULK1
Uniprot ID
O75385
功能
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation.
化学信息
分子量Theoretical: 116 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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