Anti-UCHL3 Antibody (2M552) is a Rabbit antibody targeting UCHL3. Anti-UCHL3 Antibody (2M552) can be used in WB,IHC-P,IHC-Fr,IF.

IgG

2M552

Human,Mouse,Rat

WB: 1:500-2000; IHC-P: 1:100-200; IHC-Fr: 1:100-200; IF: 1:100-200

Monoclonal

A synthesized peptide: human UCHL3

Human

UCHL3

Ubiquitin carboxyl-terminal hydrolase isozyme L3

Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3". Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory.