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Anti-Ube2L3 Polyclonal Antibody

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货号 TMAB-13937

Anti-Ube2L3 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Ube2L3。Anti-Ube2L3 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF,ELISA。

Anti-Ube2L3 Polyclonal Antibody

Anti-Ube2L3 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-13937

Anti-Ube2L3 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Ube2L3。Anti-Ube2L3 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF,ELISA。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

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产品描述
Anti-Ube2L3 Polyclonal Antibody is a Rabbit antibody targeting Ube2L3. Anti-Ube2L3 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF,ELISA.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Cow,Horse,Rabbit,Zebrafish,Sheep)
应用WBIHC-PIHC-FrIFELISA
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Cytoplasm.
组织特异性Ubiquitous, with highest expression in testis.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. The first step requires the ATP-dependent activation of the Ub C-terminus and the assembly of multi-Ub chains by the Ub-activating enzyme known as the E1 component. The Ub chain is then conjugated to the Ub-conjugating enzyme (E2) to generate an intermediate Ub-E2 complex. The Ub-ligase (E3) then catalyzes the transfer of Ub from E2 to the appropriate protein substrate. UBE2E1 and UBE2L3, also designated UBCH6 and UBCH7 respectively in human, are E2 conjugating enzymes that interact with various proteins. Specifically, UBE2E1 interacts with the tumor suppressor protein TSSC5. UBE2L3 has been shown to mediate c-fos degradation, NF-kB maturation, human papilloma virus-mediated p53 and Myc protein degradation.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Ube2L3
抗原种属
Human
基因名称
UBE2L3
基因ID
7332
蛋白名称
Ubiquitin-conjugating enzyme E2 L3
Uniprot ID
P68036
功能
Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.
化学信息
分子量Theoretical: 18 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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