Anti-UBE2L3 Antibody (5N729) is a Rabbit antibody targeting UBE2L3. Anti-UBE2L3 Antibody (5N729) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF.

IgG

5N729

Human,Mouse,Rat

WB: 1:1000-2000; IHC-P: 1:100-200; IHC-Fr: 1:100-200; ICC/IF: 1:50-200; IF: 1:50-200

Monoclonal

A synthesized peptide: human UBE2L3

Human

UBE2L3

Ubiquitin-conjugating enzyme E2 L3

Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.