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Anti-TSPO/PBR Polyclonal Antibody

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货号 TMAB-13876

Anti-TSPO/PBR Polyclonal Antibody 是一种 Rabbit 抗体，靶向 TSPO/PBR。Anti-TSPO/PBR Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF,FCM。

Anti-TSPO/PBR Polyclonal Antibody

Anti-TSPO/PBR Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-13876

Anti-TSPO/PBR Polyclonal Antibody 是一种 Rabbit 抗体，靶向 TSPO/PBR。Anti-TSPO/PBR Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF,FCM。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-TSPO/PBR Polyclonal Antibody is a Rabbit antibody targeting TSPO/PBR. Anti-TSPO/PBR Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,FCM.
Ig Type
IgG
反应种属
Human,Mouse,Rat (predicted:Dog,Pig)
应用IHC-PIHC-FrIFFCM
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Mitochondrion membrane.
组织特异性Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景PBR (Peripheral type Benzodiazepine Receptor) is a ubiquitous protein (18 kDa) found in most steroidogenic tissues. It is located primarily in the outer mitochondrial membrane of steroid producing tissues and is found in association with a 34 kDa voltage dependent anion channel protein (VDAC). PBR interacts with some benzodiazepines and has different affinities than its endogenous counterpart. PBR appears to be a key factor in the transport of cholesterol from the outer to the inner mitochondrial membrane to permit the initiation of steroid hormone synthesis. It is thought to be part of the mitochondrial permeability transition pore (PT) and to be involved in apoptosis. It is speculated that patients with congenital lipoid adrenal hyperplasia, who cannot make any steroids, might have a genetic lesion in BZRP. A short form, PBRS is also expressed in the same tissues, but at a level about ten times that of PBR.
抗原信息
免疫原
KLH conjugated synthetic peptide: human PBR
抗原种属
Human
基因名称
TSPO
基因ID
706
蛋白名称
Putative peripheral benzodiazepine receptor-related protein
Uniprot ID
B1AH88
功能
Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells.
化学信息
分子量Theoretical: 18 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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