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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-TRIM5 gamma Polyclonal Antibody

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货号 TMAB-13785

Anti-TRIM5 gamma Polyclonal Antibody 是一种 Rabbit 抗体，靶向 TRIM5 gamma。Anti-TRIM5 gamma Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-TRIM5 gamma Polyclonal Antibody

Anti-TRIM5 gamma Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-13785

Anti-TRIM5 gamma Polyclonal Antibody 是一种 Rabbit 抗体，靶向 TRIM5 gamma。Anti-TRIM5 gamma Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

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产品描述
Anti-TRIM5 gamma Polyclonal Antibody is a Rabbit antibody targeting TRIM5 gamma. Anti-TRIM5 gamma Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Rat (predicted:Human)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm, P-body.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景TRIM5a is a 493 amino acid member of the large tripartite motif protein (TRIM) family. TRIM proteins are composed of three zinc-binding domains, a RING, a B-box 2 and a coiled-coil domain, and they use homomultimerization to identify different cell compartments. Some TRIM proteins, such as TRIM5? also possess a carboxy-terminal B30.2 (SPRY) domain and localize to the cytoplasm. TRIM5?mediates innate intracellular retroviral resistance, which is dependent on its carboxy-terminal domain. The three variable regions of the B30.2 domain form loops on one side of the B30.2 core structure of TRIM5?which may form a binding surface for the virus. TRIM5?trimerization plays a major role in its affinity for the retroviral capsid, and in its ability to inhibit virus infection. The linker region between the coiled-coil and B30.2 domains of TRIM5?is required for this trimerization. TRIM5?blocks infection after the virus has entered the cell.
抗原信息
免疫原
KLH conjugated synthetic peptide: human TRIM5 gamma
抗原种属
Human
基因名称
TRIM5
基因ID
85363
蛋白名称
Tripartite motif-containing protein 5
Uniprot ID
Q9C035
功能
Isoform Alpha is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection. Targets retroviral capsid soon after entry into the cell, and prevents reverse transcription of the virus RNA genome. Isoform Alpha trimers may make multiple contacts with the hexameric lattice of CA proteins which constitute the surface of retrovirion core, and somehow inactivate the virus. Restricts efficiently infection by N-MLV, but not HIV-1. May have E3 ubiquitin-protein ligase activity.
化学信息
分子量Theoretical: 40 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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