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Anti-Transglutaminase 2 Antibody (4P75)

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货号 TMAB-13734

Anti-Transglutaminase 2 Antibody (4P75) 是一种 Mouse 抗体，靶向 Transglutaminase 2。Anti-Transglutaminase 2 Antibody (4P75) 可用于 ICC/IF, IF, IHC-Fr, IHC-P, WB。

Anti-Transglutaminase 2 Antibody (4P75)

Anti-Transglutaminase 2 Antibody (4P75)

一键复制产品信息
Rating icon 还可以
货号 TMAB-13734

Anti-Transglutaminase 2 Antibody (4P75) 是一种 Mouse 抗体，靶向 Transglutaminase 2。Anti-Transglutaminase 2 Antibody (4P75) 可用于 ICC/IF, IF, IHC-Fr, IHC-P, WB。

规格价格库存数量
25 μL
¥ 790
5日内发货
50 μL
¥ 1,395
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-Transglutaminase 2 Antibody (4P75) is a Mouse antibody targeting Transglutaminase 2. Anti-Transglutaminase 2 Antibody (4P75) can be used in ICC/IF, IF, IHC-Fr, IHC-P, WB.
Ig Type
IgG1
克隆号
4P75
反应种属
Human
验证活性
1. 25 ug total protein per lane of various lysates (see on figure) probed with Transglutaminase 2 monoclonal antibody, unconjugated (TMAB-13734) at 1: 1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min.
2. Paraformaldehyde-fixed, paraffin embedded Human Lung; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with Transglutaminase 2 Monoclonal Antibody, Unconjugated (TMAB-13734) at 1:200 overnight at 4°C, followed by conjugation to the HRP and DAB staining.
3. Paraformaldehyde-fixed, paraffin embedded Human Colon; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with Transglutaminase 2 Monoclonal Antibody, Unconjugated (TMAB-13734) at 1:200 overnight at 4°C, followed by conjugation to the HRP and DAB staining.
4. Paraformaldehyde-fixed, paraffin embedded Human Placenta; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with Transglutaminase 2 Monoclonal Antibody, Unconjugated (TMAB-13734) at 1:200 overnight at 4°C, followed by conjugation to the HRP and DAB staining.
5. Paraformaldehyde-fixed, paraffin embedded Human Breast Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with Transglutaminase 2 Monoclonal Antibody, Unconjugated (TMAB-13734) at 1:200 overnight at 4°C, followed by conjugation to the HRP and DAB staining.
6. Paraformaldehyde-fixed, paraffin embedded Human Gastric Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with Transglutaminase 2 Monoclonal Antibody, Unconjugated (TMAB-13734) at 1:200 overnight at 4°C, followed by conjugation to the HRP and DAB staining.
7. 4% Paraformaldehyde-fixed HUVEC (H) cell; Triton X-100 at r. T. for 20 min; Antibody incubation with (Transglutaminase 2) monoclonal Antibody, unconjugated 1: 100, 90 min at 37°C; followed by BF488 conjugated Goat Anti-Mouse IgG antibody (green, BF488) at 37°C for 90 min, DAPI (blue) was used to stain the cell nuclei. PBS instead of the primary antibody was used as the blank control.
应用ICC/IFIFIHC-FrIHC-PWB
推荐剂量
ICC/IF=1:50-200; IF=1:200-800; IHC-Fr=1:200-800; IHC-P=1:200-800; WB=1:500-2000
抗体种类
Monoclonal
宿主来源Mouse
构建方式Recombinant Antibody
纯化方式Affinity Purification
性状Liquid
缓冲液PBS with 100 μg/ml BSA, 0.15% ProClin300 and 50% glycerol.
研究背景Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively. Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis. Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54. Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses. When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds. Plays a key role during apoptosis, both by (1) promoting the cross-linking of cytoskeletal proteins resulting in condensation of the cytoplasm, and by (2) mediating cross-linking proteins of the extracellular matrix, resulting in the irreversible formation of scaffolds that stabilize the integrity of the dying cells before their clearance by phagocytosis, thereby preventing the leakage of harmful intracellular components.
抗原信息
免疫原
Recombinant Protein: Human TGM2 protein
抗原种属
Human
基因名称
TGM2
基因ID
7052
蛋白名称
Protein-glutamine gamma-glutamyltransferase 2
Uniprot ID
P21980
功能
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
化学信息
分子量Theoretical: 78 kDa. Actual: 78 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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