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顶部生物活性储存和溶解信息计算器

Anti-Transferrin R2 Antibody (5U818)

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Anti-Transferrin R2 Antibody (5U818)
产品编号 TMAC-04110
别名 Trfr2, Transferrin receptor protein 2, TfR2, Tfr2

Anti-Transferrin R2 Antibody (5U818) 是一种 Rabbit 抗体，靶向 Transferrin R2。Anti-Transferrin R2 Antibody (5U818) 可用于 WB,IHC。

Anti-Transferrin R2 Antibody (5U818)

Anti-Transferrin R2 Antibody (5U818)

Rating icon 还可以
Anti-Transferrin R2 Antibody (5U818)
产品编号 TMAC-04110 别名 Trfr2, Transferrin receptor protein 2, TfR2, Tfr2

Anti-Transferrin R2 Antibody (5U818) 是一种 Rabbit 抗体，靶向 Transferrin R2。Anti-Transferrin R2 Antibody (5U818) 可用于 WB,IHC。

规格价格库存数量
50 μL
¥ 1,495
5日内发货
100 μL
¥ 2,495
5日内发货
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产品介绍

生物活性
产品描述
Anti-Transferrin R2 Antibody (5U818) is a Rabbit antibody targeting Transferrin R2. Anti-Transferrin R2 Antibody (5U818) can be used in WB,IHC.
别名Trfr2, Transferrin receptor protein 2, TfR2, Tfr2
Ig Type
IgG
交叉反应
Human
验证活性
1. Western blot analysis of Transferrin Receptor 2 on HepG2 cell using anti-Transferrin Receptor 2 antibody at 1/1,000 dilution.
2. Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-Transferrin Receptor 2 antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-Transferrin Receptor 2 antibody. Counter stained with hematoxylin.
应用
WB
IHC
推荐剂量
WB: 1:500-2000; IHC: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Iron is a vital molecule for living organisms because it is involved in a wide variety of metabolic processes, such as oxygen transport, DNA synthesis and electron transport. Excessive iron uptake leads to tissue damage as a result of formation of free radicals. Iron uptake and storage is tightly regulated by the feedback system of iron responsive element-containing gene products and iron regulatory proteins that modulate the expression levels of the genes involved in iron metabolism. The transferrin receptor 2 (TFR2) mediates the uptake of transferrin-bound iron. It is involved in iron metabolism, hepatocyte function and erythrocyte differentiation, and is highly expressed as a protein in liver as well as in hepatocytes and erythroid precursors. The gene encoding human TRF2 maps to chromosome 7q22 and is expressed as an a isoform, which encodes a transmembrane protein, and a b isoform, which encodes a shorter, intracellular protein. Mutations in the TFR2 gene result in hereditary hemochromatosis type III (HFE3), an iron overloading disorder that results in clinical complications, including cirrhosis, cardiopathy, diabetes, endocrine dysfunctions, arthropathy and susceptibility to liver cancer.
偶联与修饰
偶联
Unconjugated
抗原信息
Uniprot ID
Q9UP52
化学信息
分子量Theoretical: 89 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

Trfr 2Tfr 2

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