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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-TPOR Polyclonal Antibody

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货号 TMAB-13699

Anti-TPOR Polyclonal Antibody 是一种 Rabbit 抗体，靶向 TPOR。Anti-TPOR Polyclonal Antibody 可用于 WB,FCM。

Anti-TPOR Polyclonal Antibody

Anti-TPOR Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-13699

Anti-TPOR Polyclonal Antibody 是一种 Rabbit 抗体，靶向 TPOR。Anti-TPOR Polyclonal Antibody 可用于 WB,FCM。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-TPOR Polyclonal Antibody is a Rabbit antibody targeting TPOR. Anti-TPOR Polyclonal Antibody can be used in WB,FCM.
Ig Type
IgG
反应种属
Human,Mouse (predicted:Rat,Dog,Sheep)
应用WBFCM
推荐剂量
WB: 1:500-2000; FCM: 3μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Membrane.
组织特异性Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and isoform 2 are always found to be coexpressed.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008]
抗原信息
免疫原
KLH conjugated synthetic peptide: human TPOR
抗原种属
Human
基因名称
MPL
基因ID
4352
蛋白名称
Thrombopoietin receptor
Uniprot ID
P40238
功能
Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses.
化学信息
分子量Theoretical: 68 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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