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顶部产品介绍偶联与修饰抗原信息化学信息储存和溶解信息计算器

Anti-TP53 Monoclonal Antibody (1Y943)

Synonyms: TRP53, P53, LFS1, BMFS5, BCC7
货号 TMAT-0691 一键复制产品信息
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Anti-TP53 Monoclonal Antibody (1Y943) 是一种 Mouse 抗体，靶向 TP53。Anti-TP53 Monoclonal Antibody (1Y943) 可用于 WB,IHC。

Anti-TP53 Monoclonal Antibody (1Y943)

一键复制产品信息
Rating icon 还可以
货号 TMAT-0691

别名 TRP53, P53, LFS1, BMFS5, BCC7

Anti-TP53 Monoclonal Antibody (1Y943) 是一种 Mouse 抗体，靶向 TP53。Anti-TP53 Monoclonal Antibody (1Y943) 可用于 WB,IHC。

Anti-TP53 Monoclonal Antibody (1Y943)
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产品介绍

生物活性
产品描述
Anti-TP53 Monoclonal Antibody (1Y943) is a Mouse antibody targeting TP53. Anti-TP53 Monoclonal Antibody (1Y943) can be used in WB,IHC.
别名
TRP53, P53, LFS1, BMFS5, BCC7
Ig Type
IgG1
克隆号
1Y943
反应种属
Human
应用WBIHC
推荐剂量
WB: 1/500-1/2000; IHC: 1/200-1/1000
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式Purified by protein A or protein G
性状Liquid
缓冲液PBS with 0.05% sodium azide.
浓度1 mg/mL
研究背景p53 responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Purified recombinant fragment of human p53 expressed in E. Coli.
抗原种属
Human
基因名称
TP53
基因ID
7157
蛋白名称
Cellular tumor antigen p53
Uniprot ID
P04637
化学信息
分子量Theoretical: 43.7 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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  • 配液 计算器
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