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Anti-TLR2 Antibody (5A444)
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产品编号 TMAY-00202
别名 toll-like receptor 2
Anti-TLR2 Antibody (5A444) 是一种 Mouse 抗体，靶向 TLR2。Anti-TLR2 Antibody (5A444) 可用于 IHC-P。
Anti-TLR2 Antibody (5A444)
331 Anti-TLR2 Antibody (5A444)
还可以产品编号 TMAY-00202 别名 toll-like receptor 2
Anti-TLR2 Antibody (5A444) 是一种 Mouse 抗体，靶向 TLR2。Anti-TLR2 Antibody (5A444) 可用于 IHC-P。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,689 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-TLR2 Antibody (5A444) is a Mouse antibody targeting TLR2. Anti-TLR2 Antibody (5A444) can be used in IHC-P. |
| 别名 | toll-like receptor 2 |
| Ig Type | Mouse IgG1 |
| 克隆号 | 5A444 |
| 交叉反应 | Human |
| 验证活性 | Immunochemical staining of human TLR2 in human brain with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:50-1:200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TLR2 (CD282) (rh TLR2 (CD282); TMPY-02794; O60603-1; Met1-Arg587). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | TLR2, also known as CD282, is a member of the Toll-like receptor (TLR) family. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They play a fundamental role in pathogen recognition and activation of innate immunity. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR2 contains 14 LRR (leucine-rich) repeats and 1 TIR domain. TLR2 gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. CD282 cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. It also cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. CD282 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. It may also promote apoptosis in response to lipoproteins. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human TLR2 (CD282) Protein (TMPY-02794) |
| 抗原种属 | Human |
| 研究领域 | Neuroinflammation |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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