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Anti-TIM-3/KIM-3/HAVCR2 Antibody-HRP (8Q22)
还可以产品编号 TMAY-00745H
Anti-TIM-3/KIM-3/HAVCR2 Antibody-HRP (8Q22) 是一种 HRP-conjugated Mouse 抗体，靶向 TIM-3/KIM-3/HAVCR2。Anti-TIM-3/KIM-3/HAVCR2 Antibody-HRP (8Q22) 可用于 ELISA。
Anti-TIM-3/KIM-3/HAVCR2 Antibody-HRP (8Q22)
Anti-TIM-3/KIM-3/HAVCR2 Antibody-HRP (8Q22)
还可以产品编号 TMAY-00745H
Anti-TIM-3/KIM-3/HAVCR2 Antibody-HRP (8Q22) 是一种 HRP-conjugated Mouse 抗体，靶向 TIM-3/KIM-3/HAVCR2。Anti-TIM-3/KIM-3/HAVCR2 Antibody-HRP (8Q22) 可用于 ELISA。
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-TIM-3/KIM-3/HAVCR2 Antibody-HRP (8Q22) is a HRP-conjugated Mouse antibody targeting TIM-3/KIM-3/HAVCR2. Anti-TIM-3/KIM-3/HAVCR2 Antibody-HRP (8Q22) can be used in ELISA. |
| Ig Type | Monoclonal Mouse IgG2b |
| 克隆号 | 8Q22 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 0.1-1 μg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TIMD3 (rh TIMD3; TMPY-01621; AAL65157.1; Met 1-Arg 200), and conjugated with horseradish-peroxidase (HRP). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography . |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Hepatitis A virus cellular receptor 2 (HAVCR2), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. It was the first surface molecule that specifically identifies Th1 cells in both the mouse and human. Recently, the identification of Galectin-9 as a ligand for TIM-3 has established the TIM-3-Galectin-9 pathway as an important regulator of Th1 immunity and tolerance induction. Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFN-gamma secretion and influences the ability to induce T cell tolerance in both mice and man. It suggests a novel paradigm in which dysregulation of the TIM-3-galectin-9 pathway could underlie chronic autoimmune disease states, such as multiple sclerosis. Recent work has explored the role of TIM-3 in systemic lupus erythematosus (SLE), and their results indicate that TIM-3 may represent a novel target for the treatment of SLE. Numerous studies have demonstrated that Tim-3 influences autoimmune diseases, including diabetes and multiple sclerosis, and its role in other inflammatory diseases including allergies and cancer is beginning to become clear. In the tumor rejection model, the soluble form of Tim-3 (sTim-3) significantly impaired T cell antitumor immunity, evidenced by decreased antitumor CTL activity and reduced amount of tumor-infiltrating lymphocytes in the tumor. sTim-3 as an immunoregulatory molecule that may be involved in the negative regulation of T cell-mediated immune response.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
| 偶联 | HRP |
| 其他可选修饰符 | Unconjugated |
| 可提供抗体种类 | 2 |
| 免疫原 | Recombinant Human TIMD3 protein (TMPY-01621) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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