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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Thrombomodulin Polyclonal Antibody 2

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货号 TMAB-13520

Anti-Thrombomodulin Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Thrombomodulin。Anti-Thrombomodulin Polyclonal Antibody 2 可用于 WB。

Anti-Thrombomodulin Polyclonal Antibody 2

Anti-Thrombomodulin Polyclonal Antibody 2

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Rating icon 还可以
货号 TMAB-13520

Anti-Thrombomodulin Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Thrombomodulin。Anti-Thrombomodulin Polyclonal Antibody 2 可用于 WB。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-Thrombomodulin Polyclonal Antibody 2 is a Rabbit antibody targeting Thrombomodulin. Anti-Thrombomodulin Polyclonal Antibody 2 can be used in WB.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Dog,Cow,Sheep)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Membrane; Single-pass type I membrane protein.
组织特异性Endothelial cells are unique in synthesizing thrombomodulin.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.
浓度1mg/ml
研究背景Thrombomodulin, TM is cell surface glycoprotein; plays an important role in the protein C anticoagulant pathway. It located in a vein, artery and capillary endothelial cells on the surface of plasma membrane protein. It is generally believed: TM vascular endothelial injury is an important parameter is the thrombin receptor, known in a variety of normal human tissues, can also be expressed in many tumors, TM may be similar to the E-cadherin,and is a lectin Like activity of a new class of members of the cell adhesion molecules. CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high-affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Thrombomodulin
抗原种属
Human
基因名称
THBD
基因ID
7056
蛋白名称
Thrombomodulin
Uniprot ID
P07204
功能
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
化学信息
分子量Theoretical: 61 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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