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顶部产品介绍偶联与修饰抗原信息储存和溶解信息计算器

Anti-TBC1D4 Monoclonal Antibody (5N109)

Synonyms: NIDDM5, AS160
货号 TMAT-0594 一键复制产品信息
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Anti-TBC1D4 Monoclonal Antibody (5N109) 是一种 Mouse 抗体，靶向 TBC1D4。Anti-TBC1D4 Monoclonal Antibody (5N109) 可用于 FCM。

Anti-TBC1D4 Monoclonal Antibody (5N109)

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Rating icon 还可以
货号 TMAT-0594

别名 NIDDM5, AS160

Anti-TBC1D4 Monoclonal Antibody (5N109) 是一种 Mouse 抗体，靶向 TBC1D4。Anti-TBC1D4 Monoclonal Antibody (5N109) 可用于 FCM。

Anti-TBC1D4 Monoclonal Antibody (5N109)
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产品介绍

生物活性
产品描述
Anti-TBC1D4 Monoclonal Antibody (5N109) is a Mouse antibody targeting TBC1D4. Anti-TBC1D4 Monoclonal Antibody (5N109) can be used in FCM.
别名
NIDDM5, AS160
Ig Type
IgG1
克隆号
5N109
反应种属
Human
应用FCM
推荐剂量
FCM: 1/200-1/400
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式Purified by protein A or protein G
性状Liquid
缓冲液PBS with 0.05% sodium azide
浓度1 mg/ml
研究背景This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion. Alternative splicing results in multiple transcript variants encoding different isoforms.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Purified recombinant fragment of human TBC1D4 (AA: 574-712) expressed in E. Coli.
抗原种属
Human
基因名称
TBC1D4
基因ID
9882
蛋白名称
TBC1 domain family member 4
Uniprot ID
O60343
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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