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Anti-STK3 Antibody (7H202)
还可以产品编号 TMAH-01144
别名 STK 3, STE20-like kinase MST2, Serine/threonine-protein kinase Krs-1, Serine/threonine-protein kinase 3, MST-2, MST2, Mammalian STE20-like protein kinase 2, KRS1, EC 2.7.11.1
Anti-STK3 Antibody (7H202) 是一种抗体，靶向 STK3。Anti-STK3 Antibody (7H202) 可用于 ELISA, WB。
Anti-STK3 Antibody (7H202)
Anti-STK3 Antibody (7H202)
还可以产品编号 TMAH-01144 别名 STK 3, STE20-like kinase MST2, Serine/threonine-protein kinase Krs-1, Serine/threonine-protein kinase 3, MST-2, MST2, Mammalian STE20-like protein kinase 2, KRS1, EC 2.7.11.1
Anti-STK3 Antibody (7H202) 是一种抗体，靶向 STK3。Anti-STK3 Antibody (7H202) 可用于 ELISA, WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,310 | 5日内发货 | |
| 100 μL | ¥ 2,185 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-STK3 Antibody (7H202) is an antibody targeting STK3. Anti-STK3 Antibody (7H202) can be used in ELISA, WB. |
| 别名 | STK 3, STE20-like kinase MST2, Serine/threonine-protein kinase Krs-1, Serine/threonine-protein kinase 3, MST-2, MST2, Mammalian STE20-like protein kinase 2, KRS1, EC 2.7.11.1 |
| Ig Type | Rabbit IgG |
| 克隆号 | 7H202 |
| 交叉反应 | Human |
| 验证活性 | Western Blot -Positive WB detected in: U251 whole cell lysate, U87 whole cell lysate, MCF-7 whole cell lysate, Hela whole cell lysate -All lanes: STK3 antibody at 1:2000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 57, 60 kDa -Observed band size: 50-70 kDa |
| 应用 | ELISA, WB |
| 推荐剂量 | WB:1:500-1:2000. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cytoplasm. Nucleus. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1. Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human STK3 |
| 抗原种属 | Human |
| 基因ID | 6788 |
| Uniprot ID | |
| 研究领域 | Cell biology, Signal transduction |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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