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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-SRGAP1 Polyclonal Antibody

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货号 TMAB-13156

Anti-SRGAP1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 SRGAP1。Anti-SRGAP1 Polyclonal Antibody 可用于 WB。

Anti-SRGAP1 Polyclonal Antibody

Anti-SRGAP1 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-13156

Anti-SRGAP1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 SRGAP1。Anti-SRGAP1 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-SRGAP1 Polyclonal Antibody is a Rabbit antibody targeting SRGAP1. Anti-SRGAP1 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
组织特异性Expressed in brain, lung, kidney, and testis.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景SRGAPs contain a highly conserved overall primary structure and play an important role in the cell facilitating Slit-robo signaling in cell migration and axon guidance. SRGAP1 (Slit-robo Rho GTPase activating protein 1), also known as ARHGAP13 (Rho GTPase activating protein 13), functions as a GTPase-activating protein for Cdc42 and Rho A. Expressed in kidney, testis, lung and brain, SRGAP1 contains an FCH (Fes/CIP4 homology) domain, a Rho-GAP domain and an SH3 domain. In the presence of Slit, SRGAP1 (via its SH3 domain) binds to the CC3 motif in robo (a protein responsible for mediating the repulsive effect of Slit) with higher affinity and inhibits Cdc42 activity in a robo/SRGAP-dependent manner. More specifically, SRGAP1 increases the intrinsic GTPase activity of Cdc42, thereby converting it to its inactive, GDP-bound form. Inactivation of Cdc42 ultimately leads to a decrease in actin polymerization.
抗原信息
免疫原
KLH conjugated synthetic peptide: human SRGAP1
抗原种属
Human
基因名称
SRGAP1
基因ID
57522
蛋白名称
SLIT-ROBO Rho GTPase-activating protein 1
Uniprot ID
Q7Z6B7
功能
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.
化学信息
分子量Theoretical: 124 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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