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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-SOCS1 Polyclonal Antibody

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货号 TMAB-13018

Anti-SOCS1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 SOCS1。Anti-SOCS1 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF,ELISA。

Anti-SOCS1 Polyclonal Antibody

Anti-SOCS1 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-13018

Anti-SOCS1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 SOCS1。Anti-SOCS1 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF,ELISA。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-SOCS1 Polyclonal Antibody is a Rabbit antibody targeting SOCS1. Anti-SOCS1 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF,ELISA.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat)
应用WBIHC-PIHC-FrIFELISA
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Cytoplasmic vesicle. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.
组织特异性Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity (By similarity). Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor(LIF). Regulates interferon-gamma mediated sensory neuron survival. Implicated, through SOCS box binding, in ubiquitin-dependent protein degradation. High expression in thymus. Lower expression in lung and spleen.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Socs 1
抗原种属
Human
基因名称
SOCS1
基因ID
8651
蛋白名称
Suppressor of cytokine signaling 1
Uniprot ID
O15524
功能
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
化学信息
分子量Theoretical: 23 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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