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顶部产品介绍偶联与修饰抗原信息化学信息储存和溶解信息计算器

Anti-SMURF2 Antibody (2L792)

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货号 TMAC-03810

别名 SMURF2, SMAD-specific E3 ubiquitin-protein ligase 2, SMAD ubiquitination regulatory factor 2, hSMURF2, HECT-type E3 ubiquitin transferase SMURF2, E3 ubiquitin-protein ligase SMURF2

Anti-SMURF2 Antibody (2L792) 是一种 Rabbit 抗体，靶向 SMURF2。Anti-SMURF2 Antibody (2L792) 可用于 WB。

Anti-SMURF2 Antibody (2L792)

Anti-SMURF2 Antibody (2L792)

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货号 TMAC-03810 别名 SMURF2, SMAD-specific E3 ubiquitin-protein ligase 2, SMAD ubiquitination regulatory factor 2, hSMURF2, HECT-type E3 ubiquitin transferase SMURF2, E3 ubiquitin-protein ligase SMURF2

Anti-SMURF2 Antibody (2L792) 是一种 Rabbit 抗体，靶向 SMURF2。Anti-SMURF2 Antibody (2L792) 可用于 WB。

规格价格库存数量
50 μL
¥ 1,490
5日内发货
100 μL
¥ 2,495
5日内发货
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产品介绍

生物活性
产品描述
Anti-SMURF2 Antibody (2L792) is a Rabbit antibody targeting SMURF2. Anti-SMURF2 Antibody (2L792) can be used in WB.
别名SMURF2, SMAD-specific E3 ubiquitin-protein ligase 2, SMAD ubiquitination regulatory factor 2, hSMURF2, HECT-type E3 ubiquitin transferase SMURF2, E3 ubiquitin-protein ligase SMURF2
Ig Type
IgG
克隆号
2L792
反应种属
Human
验证活性
1. Western blot analysis of SMURF 2 on A431 cell using anti-SMURF 2 antibody at 1/200 dilution.
verifiedActivity
应用WB
推荐剂量
WB: 1:500
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Smurf1 and Smurf2 (SMAD ubiquitination regulatory factor-1 and 2) are members of the Hect family of proteins, which also includes the ubiquitin (Ub) E3-type ligases Nedd3 and E6-AP. E3 ligases are involved in the enzymatic reactions of the Ub conjugating pathway, which targets proteins for degradation by the 26S proteasome. Within the Ub pathway, the E3 ligases specifically catalyze the transfer of Ub from the Ub-conjugating enzymes to the individual protein substrate. As an E3 ligase, Smurf1 selectively interacts with receptor-regulated SMADs specific to the BMP pathway in order to trigger their ubiquitination and degradation. Smurf2 interacts with receptor-activated Smads (R-Smads), including Smad1, Smad2, and Smad3, but not Smad4. Although Smurf2 localizes to the nucleus, binding to Smad7 induces its export and its recruitment to the activated TGFβ receptor, where it causes degradation of Smad7.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
Q9HAU4
化学信息
分子量Theoretical: 86 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

  • 稀释 计算器

关键词

SMURF 2hSMURF 2
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