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Anti-SMURF2 Antibody (2L792)
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产品编号 TMAC-03810
别名 SMURF2, SMAD-specific E3 ubiquitin-protein ligase 2, SMAD ubiquitination regulatory factor 2, hSMURF2, HECT-type E3 ubiquitin transferase SMURF2, E3 ubiquitin-protein ligase SMURF2
Anti-SMURF2 Antibody (2L792) 是一种 Rabbit 抗体，靶向 SMURF2。Anti-SMURF2 Antibody (2L792) 可用于 WB。
Anti-SMURF2 Antibody (2L792)
Anti-SMURF2 Antibody (2L792)
还可以产品编号 TMAC-03810 别名 SMURF2, SMAD-specific E3 ubiquitin-protein ligase 2, SMAD ubiquitination regulatory factor 2, hSMURF2, HECT-type E3 ubiquitin transferase SMURF2, E3 ubiquitin-protein ligase SMURF2
Anti-SMURF2 Antibody (2L792) 是一种 Rabbit 抗体，靶向 SMURF2。Anti-SMURF2 Antibody (2L792) 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,490 | 5日内发货 | |
| 100 μL | ¥ 2,495 | 5日内发货 |
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偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-SMURF2 Antibody (2L792) is a Rabbit antibody targeting SMURF2. Anti-SMURF2 Antibody (2L792) can be used in WB. |
| 别名 | SMURF2, SMAD-specific E3 ubiquitin-protein ligase 2, SMAD ubiquitination regulatory factor 2, hSMURF2, HECT-type E3 ubiquitin transferase SMURF2, E3 ubiquitin-protein ligase SMURF2 |
| Ig Type | IgG |
| 克隆号 | 2L792 |
| 交叉反应 | Human |
| 验证活性 | 1. Western blot analysis of SMURF 2 on A431 cell using anti-SMURF 2 antibody at 1/200 dilution. |
| 应用 | |
| 推荐剂量 | WB: 1:500 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | Smurf1 and Smurf2 (SMAD ubiquitination regulatory factor-1 and 2) are members of the Hect family of proteins, which also includes the ubiquitin (Ub) E3-type ligases Nedd3 and E6-AP. E3 ligases are involved in the enzymatic reactions of the Ub conjugating pathway, which targets proteins for degradation by the 26S proteasome. Within the Ub pathway, the E3 ligases specifically catalyze the transfer of Ub from the Ub-conjugating enzymes to the individual protein substrate. As an E3 ligase, Smurf1 selectively interacts with receptor-regulated SMADs specific to the BMP pathway in order to trigger their ubiquitination and degradation. Smurf2 interacts with receptor-activated Smads (R-Smads), including Smad1, Smad2, and Smad3, but not Smad4. Although Smurf2 localizes to the nucleus, binding to Smad7 induces its export and its recruitment to the activated TGFβ receptor, where it causes degradation of Smad7. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 86 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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