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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-SMURF2 Antibody (1Q728)

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货号 TMAB-12987

Anti-SMURF2 Antibody (1Q728) 是一种 Rabbit 抗体，靶向 SMURF2。Anti-SMURF2 Antibody (1Q728) 可用于 WB。

Anti-SMURF2 Antibody (1Q728)

Anti-SMURF2 Antibody (1Q728)

一键复制产品信息
Rating icon 还可以
货号 TMAB-12987

Anti-SMURF2 Antibody (1Q728) 是一种 Rabbit 抗体，靶向 SMURF2。Anti-SMURF2 Antibody (1Q728) 可用于 WB。

规格价格库存数量
25 μL
¥ 795
5日内发货
50 μL
¥ 1,395
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-SMURF2 Antibody (1Q728) is a Rabbit antibody targeting SMURF2. Anti-SMURF2 Antibody (1Q728) can be used in WB.
Ig Type
IgG
克隆号
1Q728
反应种属
Human (predicted:Mouse,Rat)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Nucleus. Cytoplasm. Cell membrane. Membrane raft. Cytoplasmic in the presence of SMAD7. Co-localizes with CAV1, SMAD7 and TGF-beta receptor in membrane rafts.
组织特异性Widely expressed.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby down-regulating TGF-beta signaling.
抗原信息
免疫原
A synthesized peptide: human SMURF2
抗原种属
Human
基因名称
SMURF2
基因ID
64750
蛋白名称
E3 ubiquitin-protein ligase SMURF2
Uniprot ID
Q52LL1
功能
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.
化学信息
分子量Theoretical: 86 kDa. Actual: 86 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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