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Anti-SMAD7 Polyclonal Antibody 2

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货号 TMAB-12947

Anti-SMAD7 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 SMAD7。Anti-SMAD7 Polyclonal Antibody 2 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF。

Anti-SMAD7 Polyclonal Antibody 2

Anti-SMAD7 Polyclonal Antibody 2

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Rating icon 还可以
货号 TMAB-12947

Anti-SMAD7 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 SMAD7。Anti-SMAD7 Polyclonal Antibody 2 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

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产品描述
Anti-SMAD7 Polyclonal Antibody 2 is a Rabbit antibody targeting SMAD7. Anti-SMAD7 Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF.
Ig Type
IgG
反应种属
Human,Mouse,Rat
应用WBIHC-PIHC-FrICC/IFIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Cytoplasm. Note=Interaction with NEDD4L or RNF111 or induces translocation from the nucleus to the cytoplasm. TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta.
组织特异性Ubiquitous with higher expression in the lung and vascular endothelium.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
抗原信息
免疫原
KLH conjugated synthetic peptide: human MADH7
抗原种属
Human
基因名称
SMAD7
基因ID
4092
蛋白名称
Mothers against decapentaplegic homolog 7
Uniprot ID
O15105
功能
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
化学信息
分子量Theoretical: 46 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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