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Anti-SMAD6 Polyclonal Antibody 2

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货号 TMAB-12944

Anti-SMAD6 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 SMAD6。Anti-SMAD6 Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF。

Anti-SMAD6 Polyclonal Antibody 2

Anti-SMAD6 Polyclonal Antibody 2

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Rating icon 还可以
货号 TMAB-12944

Anti-SMAD6 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 SMAD6。Anti-SMAD6 Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-SMAD6 Polyclonal Antibody 2 is a Rabbit antibody targeting SMAD6. Anti-SMAD6 Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus
组织特异性Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.[provided by RefSeq, Sep 2014]
抗原信息
免疫原
KLH conjugated synthetic peptide: human SMAD6
抗原种属
Human
基因名称
SMAD6
基因ID
4091
蛋白名称
Mothers against decapentaplegic homolog 6
Uniprot ID
O43541
功能
Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.
化学信息
分子量Theoretical: 54 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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