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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Smac Polyclonal Antibody

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货号 TMAB-12932

Anti-Smac Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Smac。Anti-Smac Polyclonal Antibody 可用于 WB,ICC/IF。

Anti-Smac Polyclonal Antibody

Anti-Smac Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-12932

Anti-Smac Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Smac。Anti-Smac Polyclonal Antibody 可用于 WB,ICC/IF。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-Smac Polyclonal Antibody is a Rabbit antibody targeting Smac. Anti-Smac Polyclonal Antibody can be used in WB,ICC/IF.
Ig Type
IgG
反应种属
Human,Mouse (predicted:Rat)
应用WBICC/IF
推荐剂量
WB: 1:500-2000; ICC/IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Mitochondrion. Note=Released into the cytosol when cells undergo apoptosis.
组织特异性Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.
浓度1mg/ml
研究背景bs-1298P is one synthetic peptide derived from human Smac. This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Several alternatively spliced transcript variants that encode distinct isoforms have been described for this gene but the validity of some transcripts, and their predicted ORFs, has not been determined conclusively. The inhibitor of apoptosis (IAP) proteins regulate programmed cell death by inhibiting members of the caspase family of enzymes. A novel mammalian protein that binds to IAPs and neutralizes their inhibitory effect on caspases has been designated Smac/DIABLO. This is a mitochondrial protein that is released along with cytochrome c during apoptosis and activates the cytochrome c/Apaf-1/caspase-9 pathway. Analysis of the structural basis of Smac/DIABLO reveals that the N-terminal amino acids are required for binding of Smac/DIABLO to IAPs and activation of caspases. Smac/DIABLO is expressed in a variety of human and mouse tissues.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Smac
抗原种属
Human
基因名称
DIABLO
基因ID
56616
蛋白名称
Diablo homolog, mitochondrial
Uniprot ID
Q9NR28
功能
Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
化学信息
分子量Theoretical: 21 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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