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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-SLITRK5 Polyclonal Antibody

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货号 TMAB-12927

Anti-SLITRK5 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 SLITRK5。Anti-SLITRK5 Polyclonal Antibody 可用于 WB。

Anti-SLITRK5 Polyclonal Antibody

Anti-SLITRK5 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-12927

Anti-SLITRK5 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 SLITRK5。Anti-SLITRK5 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-SLITRK5 Polyclonal Antibody is a Rabbit antibody targeting SLITRK5. Anti-SLITRK5 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Sheep)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Membrane; Single-pass type I membrane protein.
组织特异性Expressed predominantly in the cerebral cortex of the brain but also at low levels in the spinal cord and medulla.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic å/∫ horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. SLITRK5 (SLIT and NTRK-like family, member 5), also known as LRRC11 (leucine-rich repeat-containing protein 11), is a 958 amino acid single-pass type I membrane protein that contains 16 LRR repeats and belongs to the SLITRK family. Expressed at high levels in the cerebral cortex, but also present in areas of the spinal cord and medulla, SLITRK5 functions to suppress neurite outgrowth, thereby playing a regulatory role in neuronal function. The gene encoding SLITRK5 maps to human chromosome 13, which houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome. Trisomy 13, also known as Patau syndrome, is deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections.
抗原信息
免疫原
KLH conjugated synthetic peptide: human SLITRK5
抗原种属
Human
基因名称
SLITRK5
基因ID
26050
蛋白名称
SLIT and NTRK-like protein 5
Uniprot ID
O94991
功能
SLIT and NTRK-like family 5 (SLITRK5) is a member a protein family consisting of six homologous transmembrane proteins (SLITRK1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of SLITRK proteins is highly restricted to neural and brain tumor tissues, but varies within the protein family. Like every other SLITRK protein except SLITRK1, overexpression of SLITRK5 inhibited neurite outgrowth in cultured neurons, suggesting that these proteins are involved in the control of neurite outgrowth.
化学信息
分子量Theoretical: 103 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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