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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-SKAP55 Polyclonal Antibody

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货号 TMAB-12824

Anti-SKAP55 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 SKAP55。Anti-SKAP55 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-SKAP55 Polyclonal Antibody

Anti-SKAP55 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-12824

Anti-SKAP55 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 SKAP55。Anti-SKAP55 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-SKAP55 Polyclonal Antibody is a Rabbit antibody targeting SKAP55. Anti-SKAP55 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Rat (predicted:Human,Mouse,Dog,Pig,Horse,Rabbit)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus. Cell membrane. Upon T-cell stimulation, translocates to lipid rafts at the cell membrane.
组织特异性Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis. Present in T-cells (at protein level).
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Fyb (Fyn binding protein) and the anchoring proteins SKAP55 and SKAP55-R (SKAP55-related protein) associate with the tyrosine kinase p59fyn. SKAP55 and SKAP55-R bind to Fyb through their SH3 domains and function as substrates for p59Fyn in resting T cells. SKAP55 contains an N-terminal pleckstrin homology domain and a C-terminal SH3 domain binding motif of adjacent arginine and lysine residues followed by tandem tyrosines. SKAP55-R, similar in overall structure to SKAP55, contains a coiled-coil N-terminal domain. SKAP55 associates with SLAP-130, another component of the Fyn complex, which plays a role in the regulation of signaling events initiated by lymphocyte antigen receptors leading up to T cell activation. The human SKAP55 gene maps to chromosome 17q21.32 and encodes a 359 amino acid protein.
抗原信息
免疫原
KLH conjugated synthetic peptide: human SKAP55
抗原种属
Human
基因名称
SKAP1
基因ID
8631
蛋白名称
Src kinase-associated phosphoprotein 1
Uniprot ID
Q86WV1
功能
Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.
化学信息
分子量Theoretical: 41 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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