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Anti-SIP1 Polyclonal Antibody 3

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货号 TMAB-12804

Anti-SIP1 Polyclonal Antibody 3 是一种 Rabbit 抗体，靶向 SIP1。Anti-SIP1 Polyclonal Antibody 3 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-SIP1 Polyclonal Antibody 3

Anti-SIP1 Polyclonal Antibody 3

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Rating icon 还可以
货号 TMAB-12804

Anti-SIP1 Polyclonal Antibody 3 是一种 Rabbit 抗体，靶向 SIP1。Anti-SIP1 Polyclonal Antibody 3 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-SIP1 Polyclonal Antibody 3 is a Rabbit antibody targeting SIP1. Anti-SIP1 Polyclonal Antibody 3 can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Dog,Cow,Horse,Sheep)
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.
浓度1mg/ml
研究背景SMAD regulates gene expression by interacting with different classes of transcription factors including DNA-binding multi-zinc finger proteins. SIP1, for SMAD interacting protein 1, is a member of the delta-EF1/Zfh1 family of 2-handed zinc finger/homeodomain proteins. SIP1 contains a SMAD-binding domain, a homeodomain and two clusters of zinc fingers on the N- and C-termini. SIP1, also known as SMADIP1, ZFHX1B and ZEB2 (zinc finger E-box-binding protein 2), can be induced by TGF∫ treatment. SIP1 plays a crucial role in normal embryonic development of neural structures and the neural crest. The human SIP1 gene maps to chromosome 2q22. Mutations in the SIP1 gene cause a form of Hirschsprung disease (HSCR). Patients with SIP1 mutations show mental retardation, delayed motor development, epilepsy, microcephaly, distinct facial features and/or congenital heart disease—all symptoms of HSCR.
抗原信息
免疫原
KLH conjugated synthetic peptide: human SIP1
抗原种属
Human
基因名称
ZEB2
基因ID
9839
蛋白名称
Zinc finger E-box-binding homeobox 2
Uniprot ID
O60315
功能
Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin.
化学信息
分子量Theoretical: 136 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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