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Anti-Siglec-5 Antibody (8A125)
还可以产品编号 TMAY-02064
Anti-Siglec-5 Antibody (8A125) 是一种 Mouse 抗体，靶向 Siglec-5。Anti-Siglec-5 Antibody (8A125) 可用于 FCM。
Anti-Siglec-5 Antibody (8A125)
Anti-Siglec-5 Antibody (8A125)
还可以产品编号 TMAY-02064
Anti-Siglec-5 Antibody (8A125) 是一种 Mouse 抗体，靶向 Siglec-5。Anti-Siglec-5 Antibody (8A125) 可用于 FCM。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Siglec-5 Antibody (8A125) is a Mouse antibody targeting Siglec-5. Anti-Siglec-5 Antibody (8A125) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 8A125 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human SIGLEC5(CD170) expression on human whole blood granulocytes. Cells were stained with purified anti-Human SIGLEC5(CD170), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable granulocytes. |
| 应用 | FCM |
| 推荐剂量 | FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SIGLEC5 (rh SIGLEC5; TMPY-03549; O15389; Met1-Thr 434). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | SIGLEC5 contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobulin-like) domain. It belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. SIGLEC5 is expressed by monocytic/myeloid lineage cells. It is found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. It is also expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation. SIGLEC5 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | APC/FITC/PE |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Human SIGLEC5 Protein (TMPY-03549) |
| 抗原种属 | Human |
| 研究领域 | ITIM/ITAM Immunoreceptors and Related Molecules |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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