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Anti-Siglec-3/CD33 Antibody-FITC (4C371)
还可以产品编号 TMAY-02291F
Anti-Siglec-3/CD33 Antibody-FITC (4C371) 是一种 FITC-conjugated Mouse 抗体，靶向 Siglec-3/CD33。Anti-Siglec-3/CD33 Antibody-FITC (4C371) 可用于 FCM。
Anti-Siglec-3/CD33 Antibody-FITC (4C371)
Anti-Siglec-3/CD33 Antibody-FITC (4C371)
还可以产品编号 TMAY-02291F
Anti-Siglec-3/CD33 Antibody-FITC (4C371) 是一种 FITC-conjugated Mouse 抗体，靶向 Siglec-3/CD33。Anti-Siglec-3/CD33 Antibody-FITC (4C371) 可用于 FCM。
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| 产品描述 | Anti-Siglec-3/CD33 Antibody-FITC (4C371) is a FITC-conjugated Mouse antibody targeting Siglec-3/CD33. Anti-Siglec-3/CD33 Antibody-FITC (4C371) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 4C371 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human CD33 expression on human whole blood monocytes (left panel) and granulocytes (right panel). Cells were stained with FITC conjugated anti-Human CD33. The histograms were derived from gated events with the forward and side light-scatter characteristics of viable monocytes and granulocytes. |
| 应用 | FCM |
| 推荐剂量 | 10 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD33/Siglec-3 (rh CD33/Siglec-3; TMPY-03805; AAH28152.1; Met1-His259) and conjugated with FITC under optimum conditions, the unreacted FITC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | Myeloid cell surface antigen CD33 also known as Sialic acid binding Ig-like lectin 3, CD33 antigen or Siglec-3, is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. This Single-pass type I membrane protein contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD33 /Siglec-3 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33 /Siglec-3 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33/Siglec-3 induces apoptosis in acute myeloid leukemia (in vitro). CD33/Siglec-3 can function as a sialic acid-dependent cell adhesion molecule and that binding can be modulated by endogenous sialoglycoconjugates when CD33 is expressed in a plasma membrane.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | FITC |
| 免疫原 | Recombinant Human CD33/Siglec-3 Protein (TMPY-03805) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets, ITIM/ITAM Immunoreceptors and Related Molecules |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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